Assessment of PMTCT Success Rates Based on Antiretroviral Interventions and Feeding Options: A Prospective Cohort Study
DOI:
https://doi.org/10.21106/ijma.266Keywords:
- Assessment,
- Antiretroviral Interventions,
- PMTCT,
- Success Rates,
- Feeding Options,
- Cohort
Abstract
Background: The success of any prevention of mother-to-child transmission (PMTCT) program is assessed by the proportion of HIV-exposed infants that sero-convert at the end of all risk exposures. Although adopting the best feeding option for HIV-exposed infants is one of the factors that impact PMTCT outcomes, there is limited data on the assessment of PMTCT success rates based on antiretroviral interventions and feeding options. This study assesses the success rate of PMTCT service based on antiretroviral interventions and feeding options.
Methods: Eighty-five HIV-infected mothers previously in care were enrolled in a prospective cohort study. Folders and structured questionnaires were used to extract data on mother-infant pair and the first CD4, count of infected mothers on enrolment at PMTCT clinic. Dry blood spot samples were obtained from exposed infants for early infant diagnosis.
Results were analyzed using the SPSS software. Results: The mean age of enrolled mothers was 31.3 ± 4.4 years, and an average CD4+ T-lymphocyte count of 368.6 ± 216.2 cells/µl. Seven (8.2%) of the HIV-exposed infants were positive for HIV-1 based on early infant diagnosis results. Overall PMTCT success rate (PMTCTSR) was 91.8%. HIV-1 prevalence of 5.0%, 0% and 21.1% was found among infants of patients who opted for breastfeeding, replacement feeding, and mixed feeding respectively thus yielding PMTCT success rates of 95%, 100% and 78.9%. Pediatric antiretroviral interventions success rates in HIV-exposed infants was 95.8%, 80.0% and 66.7% based on age groups ≤ 6 months, > 6 ≤ 12 months, and > 12 ≤ 18 months respectively.
Conclusion and Global Health Implications: Quality PMTCT service is vital for successful prevention of mother-to-child transmission of HIV. Implementation of more dynamic approaches such as adherence to option B+ guidelines in PMTCT service in our settings can further reduce mother-to-child transmission of HIV and improve outcomes.
Downloads
Similar Articles
- Oluwafunmilayo Funke Adeniyi, Gabriel T. Fagbenro, Foluke A. Olatona, Overweight and Obesity Among School-aged Children and Maternal Preventive Practices against Childhood Obesity in Select Local Government Areas of Lagos, Southwest, Nigeria , Vol. 8 No. 1 (2019): International Journal of Maternal and Child Health and AIDS
- Abhiruchi Galhotra, Sanjana Agrawal, Aditi Chandrakar, Effectiveness of Human Immunodeficiency Virus Index Testing: A Global Scoping Review , Vol. 14 No. Continuous (2025): International Journal of Maternal and Child Health and AIDS
- Akinyi E. Imbo, Elizabeth K. Mbuthia, Douglas N. Ngotho, Determinants of Neonatal Mortality in Kenya: Evidence from the Kenya Demographic and Health Survey 2014 , Vol. 10 No. 2 (2021): International Journal of Maternal and Child Health and AIDS
- Nemati Ali, Tazakori Zahra, Maryam Namadi Vosogh, Nazila Vosoghi, Maryam Zare, Afroz Mardi, Adham Davoud, Hamidzadeh Arbabi Yousef, Kazemzadeh Rafat, Effectiveness Comparison of Mothers’ In-person Versus Written Nutritional Education Intervention on Infant Growth in Iran , Vol. 3 No. 1 (2015): International Journal of Maternal and Child Health and AIDS
- Varun Alwadhi, Naresh Chandra Joshi, Prashant Kumar Saboth, Raghavendra Narayan Mishra, Kuldeep Martolia, Saurabh Bhargava, Sachin Gupta, Harish Kumar, Management of Newborn Respiratory Distress Using CPAP: Capacity and Readiness of Public Health Facilities in High-Focus Aspirational Districts of India , Vol. 14 No. Continuous (2025): International Journal of Maternal and Child Health and AIDS
- Elizabeth Armstrong-Mensah, Krystal Ruiz, Aminata Fofana, Victoria Hawley, Perinatal HIV Transmission Prevention: Challenges among Women Living with HIV in sub-Saharan Africa , Vol. 9 No. 3 (2020): International Journal of Maternal and Child Health and AIDS
- Elizabeth Armstrong-Mensah, David-Praise Ebiringa, Kaleb Whitfield, Jake Coldiron, Genital Chlamydia Trachomatis Infection: Prevalence, Risk Factors and Adverse Pregnancy and Birth Outcomes in Children and Women in sub-Saharan Africa , Vol. 10 No. 2 (2021): International Journal of Maternal and Child Health and AIDS
- Cabiria M. Barbosu, Lisette Alcántara, Saloni Sharma, Jahron Marriott, Oksana Babiy, Rebecca Deamer, Marcia Kindlon, Timothy Dye, The Implementation of a State-wide Rapid Initiation of Antiretroviral Therapy as a Best Practice in Primary Care Practices Using an Academic Detailing Approach: Lessons Learned from NewYork State, United States , Vol. 11 No. 1 (2022): International Journal of Maternal and Child Health and AIDS
- Ashu Michael Agbor, Karpal Singh Sohal, Nguitewou Loith Nguimfack, Elvis Tarkang, Enow O’rock George, Sudeshni Naidoo, Oral Manifestations of HIV Infection and Dental Health Needs of Children with HIV Attending HIV Treatment Clinics in Western Cameroon , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Wah W. Myint, David J. Washburn, Brian Colwell, Jay E. Maddock, Determinants of HIV Testing Uptake among Women (aged 15-49 years) in the Philippines, Myanmar, and Cambodia , Vol. 10 No. 2 (2021): International Journal of Maternal and Child Health and AIDS
<< < 6 7 8 9 10 11 12 13 14 15 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2018 Kolawole A. Fasakin, Christopher T. Omisakin, Idowu O. Adebara, Wasiu A. Ajetunmobi, Adebayo A. Adeniyi, Ayodele J. Esan, Olufunke B. Bolaji, Oluwafemi D. Ajayi, Abayomi J. Afe. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.