Assessment of PMTCT Success Rates Based on Antiretroviral Interventions and Feeding Options: A Prospective Cohort Study
DOI:
https://doi.org/10.21106/ijma.266Keywords:
- Assessment,
- Antiretroviral Interventions,
- PMTCT,
- Success Rates,
- Feeding Options,
- Cohort
Abstract
Background: The success of any prevention of mother-to-child transmission (PMTCT) program is assessed by the proportion of HIV-exposed infants that sero-convert at the end of all risk exposures. Although adopting the best feeding option for HIV-exposed infants is one of the factors that impact PMTCT outcomes, there is limited data on the assessment of PMTCT success rates based on antiretroviral interventions and feeding options. This study assesses the success rate of PMTCT service based on antiretroviral interventions and feeding options.
Methods: Eighty-five HIV-infected mothers previously in care were enrolled in a prospective cohort study. Folders and structured questionnaires were used to extract data on mother-infant pair and the first CD4, count of infected mothers on enrolment at PMTCT clinic. Dry blood spot samples were obtained from exposed infants for early infant diagnosis.
Results were analyzed using the SPSS software. Results: The mean age of enrolled mothers was 31.3 ± 4.4 years, and an average CD4+ T-lymphocyte count of 368.6 ± 216.2 cells/µl. Seven (8.2%) of the HIV-exposed infants were positive for HIV-1 based on early infant diagnosis results. Overall PMTCT success rate (PMTCTSR) was 91.8%. HIV-1 prevalence of 5.0%, 0% and 21.1% was found among infants of patients who opted for breastfeeding, replacement feeding, and mixed feeding respectively thus yielding PMTCT success rates of 95%, 100% and 78.9%. Pediatric antiretroviral interventions success rates in HIV-exposed infants was 95.8%, 80.0% and 66.7% based on age groups ≤ 6 months, > 6 ≤ 12 months, and > 12 ≤ 18 months respectively.
Conclusion and Global Health Implications: Quality PMTCT service is vital for successful prevention of mother-to-child transmission of HIV. Implementation of more dynamic approaches such as adherence to option B+ guidelines in PMTCT service in our settings can further reduce mother-to-child transmission of HIV and improve outcomes.
Downloads
Similar Articles
- Gopal K. Singh, Hyunjung Lee, Trends and Racial/Ethnic, Socioeconomic, and Geographic Disparities in Maternal Mortality from Indirect Obstetric Causes in the United States, 1999-2017 , Vol. 10 No. 1 (2021): International Journal of Maternal and Child Health and AIDS
- Ikenna J. Nwakamma, Amber Erinmwinhe, Arinzechukwu Ajogwu, Aniekan Udoh, Anne Ada-Ogoh, Mitigating Gender and Maternal and Child Health Injustices through Faith Community-Led Initiatives , Vol. 8 No. 2 (2019): International Journal of Maternal and Child Health and AIDS
- Gopal K. Singh, Mohammad Siahpush, Romuladus E. Azuine, Shanita D. Williams, Increasing Area Deprivation and Socioeconomic Inequalities in Heart Disease, Stroke, and Cardiovascular Disease Mortality Among Working Age Populations, United States, 1969-2011 , Vol. 3 No. 2 (2015): International Journal of Maternal and Child Health and AIDS
- Vatsla Dadhwal, Aparna Sharma, Kavita Khoiwal, Dipika Deka, Plaboni Sarkar, P. Vanamail, Pregnancy Outcomes in HIV-Infected Women: Experience from a Tertiary Care Center in India , Vol. 6 No. 1 (2017): International Journal of Maternal and Child Health and AIDS
- Abou Ba, Fatou K Ndiaye, Yaay J Djeng, Cecile Cames, Aminata Diack, Ousmane N’diaye, Impact of Highly Active Antiretroviral Therapy on Chronic Hepatitis B Serological Markers among Senegalese HIV Co-infected Children , Vol. 8 No. 2 (2019): International Journal of Maternal and Child Health and AIDS
- Andrew Walubo, Refuoe Baleni, Hillary Mukudu, Henry Kambafwile, Mukesh Dheda, Thanduxolo Thengwa, Tshepang Jiane, Clinical Characteristics of Children with HIV Initiated on Antiretroviral Treatment at HIV Clinics in Bloemfontein, South Africa , Vol. 10 No. 1 (2021): International Journal of Maternal and Child Health and AIDS
- Gopal K. Singh, Hyunjung Lee, Lyoung Hee Kim, Housing and Inequalities in US Life Expectancy, Child and Youth Mortality, and All-Cause and Cause-Specific Mortality, 1979-2020: Results from the National Longitudinal Mortality Study and the National Vital Statistics System , Vol. 12 No. 2 (2023): International Journal of Maternal and Child Health and AIDS
- Hyunjung Lee, Gopal K. Singh, Monthly Trends in Drug Overdose Mortality among Youth Aged 15-34 Years in the United States, 2018-2021: Measuring the Impact of the COVID-19 Pandemic , Vol. 11 No. 2 (2022): International Journal of Maternal and Child Health and AIDS
- Rachael Bonawitz, Kathleen Lucy McGlasson, Jeanette L. Kaiser, Thandiwe Ngoma, Jody Lori, Carol Boyd, Godfrey Biemba, Davidson H. Hamer, Nancy A. Scott, Maternity Waiting Home Use by HIV-positive Pregnant Women in Zambia: Opportunity for Improved Prevention of Maternal to Child Transmission of HIV , Vol. 8 No. 1 (2019): International Journal of Maternal and Child Health and AIDS
- Khadija Kofoworola Adeleye, Margaret Omowaleola Akinwaare, Prisca Olabisi Adejumo, Reproductive Plans And Utilization of Contraceptives Among Women Living With HIV , Vol. 8 No. 2 (2019): International Journal of Maternal and Child Health and AIDS
<< < 2 3 4 5 6 7 8 9 10 11 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2018 Kolawole A. Fasakin, Christopher T. Omisakin, Idowu O. Adebara, Wasiu A. Ajetunmobi, Adebayo A. Adeniyi, Ayodele J. Esan, Olufunke B. Bolaji, Oluwafemi D. Ajayi, Abayomi J. Afe. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.