Assessment of PMTCT Success Rates Based on Antiretroviral Interventions and Feeding Options: A Prospective Cohort Study
DOI:
https://doi.org/10.21106/ijma.266Keywords:
- Assessment,
- Antiretroviral Interventions,
- PMTCT,
- Success Rates,
- Feeding Options,
- Cohort
Abstract
Background: The success of any prevention of mother-to-child transmission (PMTCT) program is assessed by the proportion of HIV-exposed infants that sero-convert at the end of all risk exposures. Although adopting the best feeding option for HIV-exposed infants is one of the factors that impact PMTCT outcomes, there is limited data on the assessment of PMTCT success rates based on antiretroviral interventions and feeding options. This study assesses the success rate of PMTCT service based on antiretroviral interventions and feeding options.
Methods: Eighty-five HIV-infected mothers previously in care were enrolled in a prospective cohort study. Folders and structured questionnaires were used to extract data on mother-infant pair and the first CD4, count of infected mothers on enrolment at PMTCT clinic. Dry blood spot samples were obtained from exposed infants for early infant diagnosis.
Results were analyzed using the SPSS software. Results: The mean age of enrolled mothers was 31.3 ± 4.4 years, and an average CD4+ T-lymphocyte count of 368.6 ± 216.2 cells/µl. Seven (8.2%) of the HIV-exposed infants were positive for HIV-1 based on early infant diagnosis results. Overall PMTCT success rate (PMTCTSR) was 91.8%. HIV-1 prevalence of 5.0%, 0% and 21.1% was found among infants of patients who opted for breastfeeding, replacement feeding, and mixed feeding respectively thus yielding PMTCT success rates of 95%, 100% and 78.9%. Pediatric antiretroviral interventions success rates in HIV-exposed infants was 95.8%, 80.0% and 66.7% based on age groups ≤ 6 months, > 6 ≤ 12 months, and > 12 ≤ 18 months respectively.
Conclusion and Global Health Implications: Quality PMTCT service is vital for successful prevention of mother-to-child transmission of HIV. Implementation of more dynamic approaches such as adherence to option B+ guidelines in PMTCT service in our settings can further reduce mother-to-child transmission of HIV and improve outcomes.
Downloads
Similar Articles
- Joel M. Njah, Gregory E. Halle-Ekane, Sylvester N. Atanga, Edouard K. Tshimwanga, Felix Desembuin, Pius T. Muffih, From Option B+ to Universal “Test and Treat” in Cameroon: Identification and Evaluation of District-level Factors Associated with Retention in Care , Vol. 12 No. 2 (2023): International Journal of Maternal and Child Health and AIDS
- Amos Kankponang Laar, Belynda Amankwa, Charlotte Asiedu, Prevention-of-Mother-To-Child-Transmission of HIV Services in Sub-Saharan Africa: A Qualitative Analysis of Healthcare Providers and Clients Challenges in Ghana , Vol. 2 No. 2 (2014): International Journal of Maternal and Child Health and AIDS
- Brianna L. Smith, Sara Zizzo, Anouk Amzel, Sarah Wiant, Molly C. Pezzulo, Sarah Konopka, Rachel Golin, Alexandra C. Vrazo, Integration of Neonatal and Child Health Interventions with Pediatric HIV Interventions in Global Health , Vol. 7 No. 1 (2018): International Journal of Maternal and Child Health and AIDS
- Océane J. Parker, Duc Minh Duong, Thuy Thu Nguyen, Vui Thi Le, Utilization of Sexual and Reproductive Healthcare Services Among Young Women in Two Districts of Hanoi, Vietnam , Vol. 15 (2026): International Journal of Maternal and Child Health and AIDS
- John Humphrey, James G Carlucci, Esther Karen Wanjama, Violet Naanyu, Lindah Muli, Joy Marsha Alera, Edwin Were, Alan McGuire, Winstone Nyandiko, Gregory Zimet, Julia Jerono Songok, Kara Wools Kaloustian, Implementing WHO Differentiated Service Delivery Model for Pregnant and Breastfeeding Women and Infants Living with HIV: Insights from Kenyan Healthcare Providers , Vol. 14 No. Continuous (2025): International Journal of Maternal and Child Health and AIDS
- Vinay Kumar, Gunjan Arora, Ish Kumar Midha, Yogender Pal Gupta, Infant and Young Child Feeding Behaviors among Working Mothers in India: Implications for Global Health Policy and Practice , Vol. 3 No. 1 (2015): International Journal of Maternal and Child Health and AIDS
- Gopal K. Singh, Romuladus E. Azuine, Mohammad Siahpush, Global Inequalities in Cervical Cancer Incidence and Mortality are Linked to Deprivation, Low Socioeconomic Status, and Human Development , Vol. 1 No. 1 (2012): International Journal of Maternal and Child Health and AIDS
- Cedrina L. Calder, Heather O’Hara, Mohammad Tabatabai, Celia J. Maxwell, Salisha Marryshow, Aima A. Ahonkhai, Carolyn M. Audet, C. William Wester, Muktar H. Aliyu, Adherence to Combination Antiretroviral Therapy among Pregnant Women Enrolled in a HIV Prevention Program in Rural North-central Nigeria , Vol. 9 No. 1 (2020): International Journal of Maternal and Child Health and AIDS
- Fekadu Mazengia Alemu, Alemayehu Worku Yalew, Mesganaw Fantahun, Eta Ebasi Ashu, Antiretroviral Therapy and Pregnancy Outcomes in Developing Countries: A Systematic Review , Vol. 3 No. 1 (2015): International Journal of Maternal and Child Health and AIDS
- Karen M. Hampanda, Lisa L. Abuogi, Yusuf Ahmed, HIV-Positive Women Taking Lifelong Antiretroviral Therapy Report Better Adherence Than Women Taking Short-Course Prophylaxis During and After Pregnancy Under PMTCT Program Option A in Lusaka, Zambia , Vol. 6 No. 1 (2017): International Journal of Maternal and Child Health and AIDS
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2018 Kolawole A. Fasakin, Christopher T. Omisakin, Idowu O. Adebara, Wasiu A. Ajetunmobi, Adebayo A. Adeniyi, Ayodele J. Esan, Olufunke B. Bolaji, Oluwafemi D. Ajayi, Abayomi J. Afe. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.