Prevalence and Identification of Serum Markers Associated with Vertical Transmission of Hepatitis B in Pregnant Women in Yaounde, Cameroon
DOI:
https://doi.org/10.21106/IJMA.174Keywords:
- Hepatitis B Virus,
- Serum Markers,
- Vertical Transmission,
- Cell Hepatocellular Carcinoma,
- Cameroon
Abstract
To determine the prevalence of Hepatitis B Virus (HBV) infection in pregnant women and identify markers associated with vertical transmission of HBV.
Methods:Prospective and cross-sectional study over 10 months on 298 pregnant women attending antenatal clinics in the Cité Verte and Efoulan District hospitals in Cameroon. A dry tube blood collection was performed on all pregnant women and babies born to HBsAg-positive mothers. Serum from the women was used to test for HBsAg through immunochromatography and then confirmed by ELISA. The test for HBeAg, HBeAb and HBcAb and dosage of transaminases were performed on the serum of HBsAg-positive women. Only HBsAg was tested in babies within 24 hours after birth.
Results:HBsAg was present in 23 (7.7%) mothers while 275 (92.3%) tested negative. Due to loss to follow-up, we assessed vertical transmission in 20 babies born to20 mothers. In all, eight babies tested HBsAg-positive; six mothers tested positive with HBeAg; 10 mothers with HBeAb and two were simultaneously infected with HBV and HIV.
Conclusion and Global Health Implications:HBeAg and increase in liver transaminases were serum markers associated with the vertical transmission of HBV while HBeAb and anti-HIV therapy were protective markers. There is need to systematically screen all pregnant women for hepatitis B, follow up those that are positive, and administer a dose of gammaglobulin anti-HBs to their children to reduce the risks of chronic hepatitis and hepatocellular carcinoma (CHC) and curb mortality and morbidity due to viral hepatitis B.
Downloads
Similar Articles
- Esum Mathias Eyong, Nwana Yvette Ngwe, Claude Ngwayu Nfuksai, Loveline Lum Niba, Akoachere Jane-Francis, Prevalence of Occupational Exposure to HIV and Factors Associated with Compliance with Post-Exposure Prophylaxis Among Health Workers of the Biyem-Assi, Buea, and Limbe Health Districts of Cameroon Maternal and Child Health and AIDS , Vol. 11 No. 1 (2022): International Journal of Maternal and Child Health and AIDS
- John Humphrey, Esther Wanjama, James G. Carlucci, Violet Naanyu, Lindah Muli, Edwin Were, Alan McGuire, Winstone M. Nyandiko, Julia Songok, Gregory Zimet, Kara Wools-Kaloustian, Understanding Women’s Preferences for Prevention of Mother-to-Child HIV Transmission Services in Kenya , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Charles Kouanfack, Skinner Nguefack Lekelem, Fala Bede, Claude Ngwayu Nkfusai, Yvette Micha Nouafo, Christian Tchokonte, Nicaise Tsomo Zephirin, Pierre Joseph Fouda, Use of Trained Non-Medical Staff to Improve Access to HIV Testing Services in Africa: Implementation of the World Health Organization Opt-out Approach in Cameroon , Vol. 10 No. 1 (2021): International Journal of Maternal and Child Health and AIDS
- Wael Hafez, Sana Osman, Muneir Gador, Muhammad Aslam, Correlation Between Plasma Vitamin C Concentration and COVID-19 Outcomes among Patients Seen at a Major Hospital in the United Arab Emirates , Vol. 11 No. 2 (2022): International Journal of Maternal and Child Health and AIDS
- Constantin Tchakounté, Céline N. Nkenfou, Thibau F. Tchouangueu, Nicole M. Ngoufack, Salomon B. Tchuandom, Olivier D. Ngono, Jules-Rogers Kuiate, Alexis Ndjolo, HIV Serodiscordance among Couples in Cameroon: Effects on Sexual and Reproductive Health , Vol. 9 No. 3 (2020): International Journal of Maternal and Child Health and AIDS
- Anne Esther Njom Nlend, Pascal Avenec, Jeannette Epée Ngoué, Arsène B. Sandie, Morbidity and Mortality of HIV-Exposed Uninfected Infants in a Tertiary Referral Facility in Yaoundé, Cameroon , Vol. 12 No. 2 (2023): International Journal of Maternal and Child Health and AIDS
- Elizabeth Armstrong-Mensah, Krystal Ruiz, Aminata Fofana, Victoria Hawley, Perinatal HIV Transmission Prevention: Challenges among Women Living with HIV in sub-Saharan Africa , Vol. 9 No. 3 (2020): International Journal of Maternal and Child Health and AIDS
- Ebelechuku F. Ugochukwu, Chinyere U. Onubogu, Emeka S. Edokwe, Uchenna Ekwochi, Kenneth N. Okeke, Esther N. Umeadi, Stanley K. Onah, A Review and Analysis of Outcomes from Prevention of Mother-toChild Transmission of HIV Infant Follow-up Services at a Pediatric Infectious Diseases Unit of a Major Tertiary Hospital in Nigeria: 2007-2020 , Vol. 10 No. 2 (2021): International Journal of Maternal and Child Health and AIDS
- Anastasia Y. Bongajum, Pascal Foumane, Charlotte O. Moussi, Noel Vogue, Hycinth S. Banseka, Jujlius M. Nwobegahay, Martina L. Baye, Strengthening Maternal Death Surveillance Systems for Evidence-Based Decision Making in Sub-Saharan Africa: The Case of the Center Region in Cameroon , Vol. 10 No. 2 (2021): International Journal of Maternal and Child Health and AIDS
- Cedrina L. Calder, Heather O’Hara, Mohammad Tabatabai, Celia J. Maxwell, Salisha Marryshow, Aima A. Ahonkhai, Carolyn M. Audet, C. William Wester, Muktar H. Aliyu, Adherence to Combination Antiretroviral Therapy among Pregnant Women Enrolled in a HIV Prevention Program in Rural North-central Nigeria , Vol. 9 No. 1 (2020): International Journal of Maternal and Child Health and AIDS
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2017 Lucien Honoré Etame Sone, Roger Ahouga Voufo, Henriette Thérèse Dimodi, Michel Kengne, Cédric Gueguim, Nnanga Ngah, Julius Oben, Judith Laure Ngondi. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.