Prevalence and Identification of Serum Markers Associated with Vertical Transmission of Hepatitis B in Pregnant Women in Yaounde, Cameroon
DOI:
https://doi.org/10.21106/IJMA.174Keywords:
- Hepatitis B Virus,
- Serum Markers,
- Vertical Transmission,
- Cell Hepatocellular Carcinoma,
- Cameroon
Abstract
To determine the prevalence of Hepatitis B Virus (HBV) infection in pregnant women and identify markers associated with vertical transmission of HBV.
Methods:Prospective and cross-sectional study over 10 months on 298 pregnant women attending antenatal clinics in the Cité Verte and Efoulan District hospitals in Cameroon. A dry tube blood collection was performed on all pregnant women and babies born to HBsAg-positive mothers. Serum from the women was used to test for HBsAg through immunochromatography and then confirmed by ELISA. The test for HBeAg, HBeAb and HBcAb and dosage of transaminases were performed on the serum of HBsAg-positive women. Only HBsAg was tested in babies within 24 hours after birth.
Results:HBsAg was present in 23 (7.7%) mothers while 275 (92.3%) tested negative. Due to loss to follow-up, we assessed vertical transmission in 20 babies born to20 mothers. In all, eight babies tested HBsAg-positive; six mothers tested positive with HBeAg; 10 mothers with HBeAb and two were simultaneously infected with HBV and HIV.
Conclusion and Global Health Implications:HBeAg and increase in liver transaminases were serum markers associated with the vertical transmission of HBV while HBeAb and anti-HIV therapy were protective markers. There is need to systematically screen all pregnant women for hepatitis B, follow up those that are positive, and administer a dose of gammaglobulin anti-HBs to their children to reduce the risks of chronic hepatitis and hepatocellular carcinoma (CHC) and curb mortality and morbidity due to viral hepatitis B.
Downloads
Similar Articles
- John Humphrey, James G Carlucci, Esther Karen Wanjama, Violet Naanyu, Lindah Muli, Joy Marsha Alera, Edwin Were, Alan McGuire, Winstone Nyandiko, Gregory Zimet, Julia Jerono Songok, Kara Wools Kaloustian, Implementing WHO Differentiated Service Delivery Model for Pregnant and Breastfeeding Women and Infants Living with HIV: Insights from Kenyan Healthcare Providers , Vol. 14 No. Continuous (2025): International Journal of Maternal and Child Health and AIDS
- Cho Sabastine Anye, Claude Ngwayu Nkfusai, Brenda Mbouamba Yankam, Frankline Sevidzem Wirsiy, Joyce Mahlako Tsoka-Gwegweni, Samuel Nambile Cumber, A Four-Year Hospital-Based Retrospective Study of the Predictors of Tuberculosis in People Living with HIV and Receiving Care at Bamenda Regional Hospital, Cameroon , Vol. 9 No. 2 (2020): International Journal of Maternal and Child Health and AIDS
- Onana Akoa Francois Anicet, Charles Kouanfack, Ulrich Dama, Claude Ngwayu Nkfusai, Jean Ndibi Abanda, Désiré Tchoffo, Pearl Nsom Mbu, Pierre Yassa Yoniene, Prevalence, Epidemiological, and Clinical Profile of Patients Coinfected with Human Immunodeficiency Virus and Tuberculosis in the Coronavirus Disease 2019 Context in Health Facilities in the East Region, Cameroon , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Alexander Suuk Laar, Veioshnee Govender, Individual and Community Perspectives, Attitudes, and Practices to Mother-to-Child-Transmission and Infant Feeding among HIV-Positive Mothers in Sub-Saharan Africa: A Systematic Literature Review , Vol. 2 No. 1 (2013): International Journal of Maternal and Child Health and AIDS
- Maria Vigil-Mallette, Daryle Pickens, Julliet Ogu, Deepa Dongarwar, Elizabeth Onugha, Hamisu M Salihu, Fifth Annual Summer Research Summit on Health Equity Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on May 17, 2022 , Vol. 11 No. S2 (2022): International Journal of Maternal and Child Health and AIDS
- Armand Duclaire Kemo, Bruno Kenfack, Jerome Ateudjieu, Maternal Deaths and Complications: Documentation of Parameters on the Partographs Used by Health Care Providers in Four Hospitals in West Cameroon , Vol. 14 No. Continuous (2025): International Journal of Maternal and Child Health and AIDS
- Isaac Oludare Oluwayemi, Simeon Oladele Olatunya, Ezra Olatunde Ogundare, PCR Results and PMTCT Treatment Outcomes among HIV-Exposed Infants in a Tertiary Hospital in Nigeria, 2010-2014 , Vol. 3 No. 2 (2015): International Journal of Maternal and Child Health and AIDS
- Khadija Kofoworola Adeleye, Margaret Omowaleola Akinwaare, Prisca Olabisi Adejumo, Reproductive Plans And Utilization of Contraceptives Among Women Living With HIV , Vol. 8 No. 2 (2019): International Journal of Maternal and Child Health and AIDS
- Ahmad Abdulhadi, Nasiru Abdullahi, Ibrahim Yusuf, Basheer I. Waziri, Kasimu Mamuda , Husna F. Ibrahim, Khadija Muhammad, Maryam M. Ibrahim , Aisha A. Abdullahi, Hassan A. Murtala, Muhammad A. Abbas, Hamisu M. Salihu, A Systematic Review and Meta-analysis on Innovative Approaches in Tuberculosis Diagnosis: Challenges and Future Directions , Vol. 15 (2026): International Journal of Maternal and Child Health and AIDS
- Michelle Berlacher, Timothy Mercer, Edith O. Apondi, Winfred Mwangi, Edwin Were, Megan S. McHenry, Integrating Prevention of Mother-to-Child Transmission of HIV Care into General Maternal Child Health Care in Western Kenya , Vol. 10 No. 1 (2021): International Journal of Maternal and Child Health and AIDS
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2017 Lucien Honoré Etame Sone, Roger Ahouga Voufo, Henriette Thérèse Dimodi, Michel Kengne, Cédric Gueguim, Nnanga Ngah, Julius Oben, Judith Laure Ngondi. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.