Biochemical Manifestation of HIV Lipodystrophy Syndrome
DOI:
https://doi.org/10.21106/ijma.6Keywords:
- HIV Lipodystrophy Syndrome,
- Highly active anti-retroviral therapy,
- Nucleoside Reverse Transcriptase Inhibitors,
- buffalo hump
Abstract
Highly active anti-retroviral therapy (HAART), including protease inhibitors (PI) have led to dramatic improvements in the quality and quantity of life in patients with acquired immunodeficiency syndrome (AIDS). However, a significant number of AIDS patients on HAART develop characteristic changes in body fat redistribution referred to as lipodystrophy syndrome (LDS). Features of LDS include hypertrophy in the neck fat pad (buffalo hump), increased fat in the abdominal region (protease paunch), gynecomastia and loss of fat in the mid-face and extremities.
MethodsThe aim of this paper is to review the current knowledge regarding this syndrome. This article reviews the published investigations on biochemical manifestation of HIV lipodystrophy syndrome.
ResultsIt is estimated that approximately 64% of patients treated with PI will experience this syndrome. Biochemically, these patients have increased triglycerides (Trig), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and extremely low high-density lipoprotein-cholesterol (HDL-C).
Conclusions and Public Health ImplicationsIt is hoped that awareness of this syndrome would aid in early diagnosis and better patient management, possibly leading to a lower incidence of cardiovascular complications among these patients.
Downloads
Similar Articles
- Paul Kiondo, Annettee Nakimuli, Samuel Ononge, Julius N. Wandabwa, Milton W. Musaba, Predictors of Intrapartum Stillbirths among Women Delivering at Mulago Hospital, Kampala, Uganda , Vol. 10 No. 2 (2021): International Journal of Maternal and Child Health and AIDS
- Rafeek A. Yusuf, Deepa Dongarwar, Zenab I. Yusuf, Hamisu M. Salihu, Association between Intimate Partner Violence, Knowledge and Use of Contraception in Africa: Comparative Analysis across Five African Regions , Vol. 9 No. 1 (2020): International Journal of Maternal and Child Health and AIDS
- Mamour Gueye, Mame D. Ndiaye-Gueye, Serigne M. Kane-Gueye, Omar Gassama, Moussa Diallo, Jean C. Moreau, Diagnosis, Treatment and Outcome of Gestational Trophoblastic Neoplasia in a Low Resource Income Country , Vol. 5 No. 2 (2016): International Journal of Maternal and Child Health and AIDS
- Taranpreet Kaur, Kalpana Kumari, Priyanka Rai, Vandana Gupta, Sarika Pandey, Vineeta, Shweta Saini, A Comparative Study of Oral Nifedipine and Intravenous Labetalol for Acute Hypertensive Management in Pregnancy: Assessing Feto-Maternal Outcomes in a Hospital-based Randomized Control Trial , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Nkechi Martina Odogwu, Chinedum A. C. Onebunne, Oladapo O. Olayemi, Akinyinka O. Omigbodun, Protocol for a Longitudinal Analysis of the Vaginal Microbiome from a Pregnant Cohort of African Women in Nigeria , Vol. 9 No. 2 (2020): International Journal of Maternal and Child Health and AIDS
- Anastasia Y. Bongajum, Pascal Foumane, Charlotte O. Moussi, Noel Vogue, Hycinth S. Banseka, Jujlius M. Nwobegahay, Martina L. Baye, Strengthening Maternal Death Surveillance Systems for Evidence-Based Decision Making in Sub-Saharan Africa: The Case of the Center Region in Cameroon , Vol. 10 No. 2 (2021): International Journal of Maternal and Child Health and AIDS
- Emmanuel Numfor, Nkengafac Nyiawung Fobellah, Joel Noutakdie Tochie, Tsi Njim, Sylvester Atanga Ndesso, Oxytocin Versus Misoprostol Plus Oxytocin in the Prevention of Postpartum Hemorrhage at a Semi-Urban Hospital in sub-Saharan Africa: A Retrospective Cohort Study , Vol. 9 No. 3 (2020): International Journal of Maternal and Child Health and AIDS
- Gopal K. Singh, Hyunjung Lee, Trends and Racial/Ethnic, Socioeconomic, and Geographic Disparities in Maternal Mortality from Indirect Obstetric Causes in the United States, 1999-2017 , Vol. 10 No. 1 (2021): International Journal of Maternal and Child Health and AIDS
- Chiluba Kabalika, David Mulenga, Mazyanga Lucy Mazaba, Seter Siziya, Acceptance of Cervical Cancer Screening and its Correlates Among Women of a Peri-Urban High-Density Residential Area in Ndola, Zambia , Vol. 7 No. 1 (2018): International Journal of Maternal and Child Health and AIDS
- Fatemeh Bahreini, Rezvan Najafi, Razieh Amini, Salman Khazaei, Saeid Bashirian, Reducing False Negative PCR Test for COVID-19 , Vol. 9 No. 3 (2020): International Journal of Maternal and Child Health and AIDS
<< < 8 9 10 11 12 13 14 15 16 17 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2016 Kenneth Ihenetu, Darius Mason. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.