Biochemical Manifestation of HIV Lipodystrophy Syndrome
DOI:
https://doi.org/10.21106/ijma.6Keywords:
- HIV Lipodystrophy Syndrome,
- Highly active anti-retroviral therapy,
- Nucleoside Reverse Transcriptase Inhibitors,
- buffalo hump
Abstract
Highly active anti-retroviral therapy (HAART), including protease inhibitors (PI) have led to dramatic improvements in the quality and quantity of life in patients with acquired immunodeficiency syndrome (AIDS). However, a significant number of AIDS patients on HAART develop characteristic changes in body fat redistribution referred to as lipodystrophy syndrome (LDS). Features of LDS include hypertrophy in the neck fat pad (buffalo hump), increased fat in the abdominal region (protease paunch), gynecomastia and loss of fat in the mid-face and extremities.
MethodsThe aim of this paper is to review the current knowledge regarding this syndrome. This article reviews the published investigations on biochemical manifestation of HIV lipodystrophy syndrome.
ResultsIt is estimated that approximately 64% of patients treated with PI will experience this syndrome. Biochemically, these patients have increased triglycerides (Trig), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and extremely low high-density lipoprotein-cholesterol (HDL-C).
Conclusions and Public Health ImplicationsIt is hoped that awareness of this syndrome would aid in early diagnosis and better patient management, possibly leading to a lower incidence of cardiovascular complications among these patients.
Downloads
Similar Articles
- Mary Jane Rotheram-Borus, Mark Tomlinson, Utilizing Principles of Private Enterprise to Improve Maternal and Child Health Programs , Vol. 9 No. 2 (2020): International Journal of Maternal and Child Health and AIDS
- Veronica B. Ajewole, Ahone E. Ngujede, Emmanuella Oduguwa, Deepa Dongarwar, Manvir Kaur, Cecelia Knight, Maresha Jackson, Uyen Nguyen, Tasha Roshan, Jordan Simpson, Igor Vouffo, Omonike A. Olaleye, Hamisu M. Salihu, A Surveillance System for the Maternal and Child Health (MCH) Population During the COVID-19 Pandemic , Vol. 9 No. 3 (2020): International Journal of Maternal and Child Health and AIDS
- Ndidiamaka Amutah-Onukagha, Monica Rodriguez, Ijeoma Opara, Michelle Gardner, Maame Araba Assan, Rodney Hammond, Jesus Plata, Kimberly Pierre, Ehsan Farag, Progresses and challenges of utilizing traditional birth attendants in maternal and child health in Nigeria , Vol. 6 No. 2 (2017): International Journal of Maternal and Child Health and AIDS
- Gopal K. Singh, Stella M. Yu, Infant Mortality in the United States, 1915-2017: Large Social Inequalities have Persisted for Over a Century , Vol. 8 No. 1 (2019): International Journal of Maternal and Child Health and AIDS
- Faith Iretioluwa Olaniyi, Ayodele Ebenezer Owolabi, Gideon Temitope Olowe, Ololade Daniella Olunloyo, Eric Anuoluwapo Ogunleye, Ifeoluwapo Oluwafunke Kolawole, Perception, Pattern of Use, and Determinants of Family Planning Uptake Among Women of Childbearing Age in Ibadan, South West Nigeria , Vol. 15 (2026): International Journal of Maternal and Child Health and AIDS
- Anne Esther Njom Nlend, Mpox and Breastfeeding in Sub-Saharan Africa: Clinical, Program, and Policy Recommendations , Vol. 14 No. Continuous (2025): International Journal of Maternal and Child Health and AIDS
- Alice Rosmini, Kidza Mugerwa, Awatta Walter Ochan, Sarah Muwanguzi, Jemelia Sake, Richard Mwesigwa, Okpwoku Sukere, Catrin Schulte-Hillen, Nguyen Toan Tran, Empowering Midwives in Humanitarian Settings: Integrating Heat-Stable Carbetocin and Tranexamic Acid into Postpartum Hemorrhage Training , Vol. 13 No. S1 (2024): International Journal of Maternal and Child Health and AIDS
- Ashu Michael Agbor, Loyick Nguafack Zencha, Henri Essome, Che Bleck Ndikum, Pascal Foumane, Oral Health Status of Pregnant Women Attending Antenatal Clinic in Cameroon , Vol. 14 No. Continuous (2025): International Journal of Maternal and Child Health and AIDS
- Gopal K. Singh, Anagha Lokhande, Romuladus E. Azuine, Global Inequalities in Youth Mortality, 2007-2012 , Vol. 3 No. 1 (2015): International Journal of Maternal and Child Health and AIDS
- Ranjan Kumar Prusty, Sayeed Unisa, Reproductive Tract Infections and Treatment Seeking Behavior among Married Adolescent Women 15-19 Years in India , Vol. 2 No. 1 (2013): International Journal of Maternal and Child Health and AIDS
<< < 9 10 11 12 13 14 15 16 17 18 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2016 Kenneth Ihenetu, Darius Mason. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.