Biochemical Manifestation of HIV Lipodystrophy Syndrome
DOI:
https://doi.org/10.21106/ijma.6Keywords:
- HIV Lipodystrophy Syndrome,
- Highly active anti-retroviral therapy,
- Nucleoside Reverse Transcriptase Inhibitors,
- buffalo hump
Abstract
Highly active anti-retroviral therapy (HAART), including protease inhibitors (PI) have led to dramatic improvements in the quality and quantity of life in patients with acquired immunodeficiency syndrome (AIDS). However, a significant number of AIDS patients on HAART develop characteristic changes in body fat redistribution referred to as lipodystrophy syndrome (LDS). Features of LDS include hypertrophy in the neck fat pad (buffalo hump), increased fat in the abdominal region (protease paunch), gynecomastia and loss of fat in the mid-face and extremities.
MethodsThe aim of this paper is to review the current knowledge regarding this syndrome. This article reviews the published investigations on biochemical manifestation of HIV lipodystrophy syndrome.
ResultsIt is estimated that approximately 64% of patients treated with PI will experience this syndrome. Biochemically, these patients have increased triglycerides (Trig), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and extremely low high-density lipoprotein-cholesterol (HDL-C).
Conclusions and Public Health ImplicationsIt is hoped that awareness of this syndrome would aid in early diagnosis and better patient management, possibly leading to a lower incidence of cardiovascular complications among these patients.
Downloads
Similar Articles
- Amos Kankponang Laar, Belynda Amankwa, Charlotte Asiedu, Prevention-of-Mother-To-Child-Transmission of HIV Services in Sub-Saharan Africa: A Qualitative Analysis of Healthcare Providers and Clients Challenges in Ghana , Vol. 2 No. 2 (2014): International Journal of Maternal and Child Health and AIDS
- Hamisu M. Salihu, Global Reduction in HIV-related Maternal Mortality: ART as a Key Strategy , Vol. 4 No. 2 (2015): International Journal of Maternal and Child Health and AIDS
- Charles Kouanfack, Fala Bede, Claude Ngwayu Nkfusai, Emerson Wepngong, Mbinkar Adeline Venyuy, Chombong Hubert, Denise Movuh Sam, Samuel Nambile Cumber, Retention in HIV/AIDS Management Services: is it Really Poor? The Case of Yaounde Central Hospital in Cameroon , Vol. 9 No. 2 (2020): International Journal of Maternal and Child Health and AIDS
- Lucien Honoré Etame Sone, Roger Ahouga Voufo, Henriette Thérèse Dimodi, Michel Kengne, Cédric Gueguim, Nnanga Ngah, Julius Oben, Judith Laure Ngondi, Prevalence and Identification of Serum Markers Associated with Vertical Transmission of Hepatitis B in Pregnant Women in Yaounde, Cameroon , Vol. 6 No. 1 (2017): International Journal of Maternal and Child Health and AIDS
- Rasaki O Shittu, Baba A Issa, Ganiyu T Olanrewaju, Abdulraheem O Mahmoud, Louis O Odeigah, Abdullateef G Sule, Social Determinants of Depression: Social Cohesion, Negative Life Events, and Depression Among People Living with HIV/Aids in Nigeria, West Africa , Vol. 2 No. 2 (2014): International Journal of Maternal and Child Health and AIDS
- Sakshi Gaind, DK Suresh, Amrinder Tuli, Evaluation of Glycosylated Hemoglobin Levels and Effect of Tobacco Smoking in Periodontally Diseased Non-Diabetic Patients , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Md Nazrul Islam Mondai, Md Monzur Morshad Nasir Ullah, Md Rafiqul Islam, Md Shafiur Rahman, Md Nuruzzaman Khan, Kazi Mohiuddin Ahmed, Mohammad Shariful Islam, Sociodemographic and Health Determinants of Inequalities in Life Expectancy in Least Developed Countries , Vol. 4 No. 1 (2015): International Journal of Maternal and Child Health and AIDS
- Joseph F. Nkfusai, Simon M. Manga, Kathleen Nulah, Calvin Ngalla, Florence Manjuh, Claude Ngwayu Nkfusai, Tendongfor Nicholas, Halle Ekane Edie Gregory, Cervical Precancer Treatment Outcomes in Cameroon , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Samantha A. Slinkard, Jennifer R. Pharr, Tamara Bruno, Dina Patel, Amaka Ogidi, Michael Obiefune, Echezona E. Ezeanolue, Determinants of Infant Mortality in Southeast Nigeria: Results from the Healthy Beginning Initiative, 2013-2014 , Vol. 7 No. 1 (2018): International Journal of Maternal and Child Health and AIDS
- Charles Ikeanyionwu, Deepa Dongarwar, Zenab Yusuf, Rafeek Yusuf, Meishon Bell, Toi Harris, Hamisu M. Salihu, 2019 Health Equity Summer Research Summit Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on June 18th, 2019 , Vol. 9 No. S1 (2020): International Journal of Maternal and Child Health and AIDS
<< < 4 5 6 7 8 9 10 11 12 13 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2016 Kenneth Ihenetu, Darius Mason. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.