Biochemical Manifestation of HIV Lipodystrophy Syndrome
DOI:
https://doi.org/10.21106/ijma.6Keywords:
- HIV Lipodystrophy Syndrome,
- Highly active anti-retroviral therapy,
- Nucleoside Reverse Transcriptase Inhibitors,
- buffalo hump
Abstract
Highly active anti-retroviral therapy (HAART), including protease inhibitors (PI) have led to dramatic improvements in the quality and quantity of life in patients with acquired immunodeficiency syndrome (AIDS). However, a significant number of AIDS patients on HAART develop characteristic changes in body fat redistribution referred to as lipodystrophy syndrome (LDS). Features of LDS include hypertrophy in the neck fat pad (buffalo hump), increased fat in the abdominal region (protease paunch), gynecomastia and loss of fat in the mid-face and extremities.
MethodsThe aim of this paper is to review the current knowledge regarding this syndrome. This article reviews the published investigations on biochemical manifestation of HIV lipodystrophy syndrome.
ResultsIt is estimated that approximately 64% of patients treated with PI will experience this syndrome. Biochemically, these patients have increased triglycerides (Trig), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and extremely low high-density lipoprotein-cholesterol (HDL-C).
Conclusions and Public Health ImplicationsIt is hoped that awareness of this syndrome would aid in early diagnosis and better patient management, possibly leading to a lower incidence of cardiovascular complications among these patients.
Downloads
Similar Articles
- Ornella Sybile D. Kouanfack, Charles Kouanfack, Serges Clotaire Billong, Samuel N. Cumber, Claude N. Nkfusai, Fala Bede, Emerson Wepngong, Chombong Hubert, Georges Nguefack-Tsague, Madeleine N. Singwe, Epidemiology of Opportunistic Infections in HIV Infected Patients on Treatment in Accredited HIV Treatment Centers in Cameroon , Vol. 8 No. 2 (2019): International Journal of Maternal and Child Health and AIDS
- Onana Akoa Francois Anicet, Charles Kouanfack, Ulrich Dama, Claude Ngwayu Nkfusai, Jean Ndibi Abanda, Désiré Tchoffo, Pearl Nsom Mbu, Pierre Yassa Yoniene, Prevalence, Epidemiological, and Clinical Profile of Patients Coinfected with Human Immunodeficiency Virus and Tuberculosis in the Coronavirus Disease 2019 Context in Health Facilities in the East Region, Cameroon , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Karen M. Hampanda, Lisa L. Abuogi, Yusuf Ahmed, HIV-Positive Women Taking Lifelong Antiretroviral Therapy Report Better Adherence Than Women Taking Short-Course Prophylaxis During and After Pregnancy Under PMTCT Program Option A in Lusaka, Zambia , Vol. 6 No. 1 (2017): International Journal of Maternal and Child Health and AIDS
- Margaret Macherera Macherera, Lindani Moyo, Mkhanyiseli Ncube, Angella Gumbi, Social, Cultural, and Environmental Challenges Faced by Children on Antiretroviral Therapy in Zimbabwe: a Mixed-Method Study , Vol. 1 No. 1 (2012): International Journal of Maternal and Child Health and AIDS
- Maxwell P. Dapar, Benjamin N. Joseph, Rotkangmwa C. Okunlola, Josiah Mutihir, Moses P. Chingle, Mathilda E. Banwat, Pregnancy and Birth Outcomes Among Women on Antiretroviral Therapy: A Long-term Retrospective Analysis of Data from a Major Tertiary Hospital in North Central Nigeria , Vol. 10 No. 2 (2021): International Journal of Maternal and Child Health and AIDS
- Nathan Isabirye, Amara E. Ezeamama, Rachel Kyeyune-Bakyayita, Danstan Bagenda, Wafaie W. Fawzi, David Guwatudde, Dietary Micronutrients and Gender, Body Mass Index and Viral Suppression Among HIV-Infected Patients in Kampala, Uganda , Vol. 9 No. 3 (2020): International Journal of Maternal and Child Health and AIDS
- Fatima M. Damagum, Zainab D. Ahmed, Rabiu I. Jalo, Hamisu M. Salihu, C. William Wester, Muktar H. Aliyu, Adapted Counseling Care Model for Management of Female Sexual Dysfunction Among Women Living With and Without HIV , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Mousumi Datta, Shamima Yasmin, Rahul Biswas, Immunization Status, Immunization Coverage, and Factors Associated with Immunization Service Utilization Among HIV-Exposed and HIV-Infected Children in India , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
- Anne Esther Njom Nlend, Pascal Avenec, Jeannette Epée Ngoué, Arsène B. Sandie, Morbidity and Mortality of HIV-Exposed Uninfected Infants in a Tertiary Referral Facility in Yaoundé, Cameroon , Vol. 12 No. 2 (2023): International Journal of Maternal and Child Health and AIDS
- Fulufhedzani C. Malindi, Maria S. Maputle, Involvement of Male Partners in Sustaining Interventions for Preventing Mother-to-Child Transmission of HIV Among Women with HIV , Vol. 13 No. Continuous (2024): International Journal of Maternal and Child Health and AIDS
<< < 2 3 4 5 6 7 8 9 10 11 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2016 Kenneth Ihenetu, Darius Mason. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.